Dr. Sakaguchi: Thank you very much for your introduction, Carin. I am interested in continuing our
conversation about IC based on my experiences treating both male and female patients in my clinic. I am sure that the patients suffering from IC could be cured, and become pain
free from my experiences. My treatment is as follows:
There are two groups of medicines for the treatment of IC.One group is herbal medicine. In this group there are traditional herbal medicines from old China, and Cernilton or Eviprostatfor BPH (benign prostatic hyperplasia). For female patients I use
traditional herbal medicine. For male patients I use Cernilton or Eviprostat. The medicines in this
group alone are not so effective or no effective. I have not used Cernilton or Eviprostat for female patients yet. (In Japan these medicines are not allowed legally, but would be very useful in treating IC patients.)
In the other group there are some medicines for the treatment of chronic bronchitis. For
example IPD(*suplatast tosilate)*, lisozyme hydrochloride, proteolytic enzymes, and so on. I often use for treating IC lisozyme, for it is very cheap to obtain in Japan.
With two medicines from each groups the patients are controlled, painless, without urgency
and sense of residual urine. With only using one medicine it is very difficult or impossible to control
the symptoms of pain and urgency.
A clinical trial of IPD for the treatment of IC in Japan was implemented, but the results of the trial was all in vain unfortunately. Again, from my opinion it is impossible to treat IC with one drug from one group. When IPD was used with a medicine from the other group it was found to be most effective. Almost all patients are pain free, without urgency, but a few patients need NSAID one or two times a month.
This is my treatment protocol. I heard that in USA traditional herbal medicines from old China could
not be allowed. But they are only herbal teas. First you should use Cernilton or Eviprostat
for the male patients. These drugs are also useful for the patients with radiation cystitis the changes of which are similar to IC.
C.W. Thank you for sharing your treatment protocol for IC patients, Dr. Sakaguchi. Through my own journey towards finding relief from severe IC and Vulvodynia I did find that using both Traditional Chinese Medicine herbs and acupuncture to be effective of my pain and symptoms (along with the IC diet and some other modalities) so I believe very strongly in the effectiveness of your treatment protocol. Yes you are correct, Chinese Medicine herbs are strongly regulated here in the U.S. and I am sure they are not straight/pure strains of Chinese herbals as one might find in Chine or Japan as most have binders/fillers.
I am intrigued by your use of medicines for chronic bronchitis for helping IC patients-and I am wondering if this is similar to treating some of the IC related pain and symptoms of U.S. patients with antihistamines which has shown some success? As one doctor explained a lot of IC patients seem to have histamine issues within their bladders and see an increase in their pain/symptoms during allergy season (for example during spring and autumn months). Have you found this connection with your IC patients?
Dr. Sakaguchi:Certainly some patients are cured by a single medicine, for example Chinese herbal medicines, but the rest of the patients were never cured by them. I think that so far any treatment of the patients
with severe pain is not currently in existence. We need a treatment for all
patients with IC. I also tried acupuncture for some patients with severe pain, the condition of bladder inflammation becomes worse. The cause of IC is obscure, so I can not say exactly. The drugs of allergy is also used in Japan, IPD. Some patients are cured by it, but not all. Lisozyme from egg and Mucosolvan, which are useful for IC, are not a drug for allergy. So the process of treating IC is different from treating allergy only. But there is a good news. My two patients who stopped taking the lisozyme and there pain became worse. I said them to drink raw egg. After some days they feel better again. (In Japan raw eggs are often used for breakfast.)
C.W. You have provided us with a lot of interesting information about treating IC with a combination of holistic (Chinese) herbals combined with synthetic medicine. Are you publishing any of your current work so that you can get further credit and funding for your work treating IC patients? I can tell that you have been working hard to solve the mystery of IC. Thanks so much for your work!
Dr. Sakaguchi: I am going to write a paper or a case report about my current treatment of IC patients.
C.W. Thank you, once again Dr. Sakaguchi, for your work treating IC patients in Japan and for sharing some of your treatment protocol with us. I look forward to hearing more about your work in the future.
Dr. Sakaguchi. Thank you for allowing me the opportunity to have this interview and to share my treatment of IC patients. It is my wish that the patients with IC become happy and healthy once again.
C.W. More information about Dr. Tsuyoshi Sakaguchi's work with IC patients in Japan can be found here: